####

#### Purpose

The aim of this study was to report 3 cases of persistent epithelial defects (PEDs) successfully treated with the combined topical application of a regenerative agent (RGTA; Cacicol20, OTR3, Paris, France) with a bandage contact lens (BCL).

#### Methods

This is a case series.

#### Results

Three patients suffering from a PED for 4–8 weeks and unresponsive to conventional therapy were treated with the combined application of an RGTA (Cacicol20) and a silicon hydrogel BCL. The PED healed in all patients after 4–21 days, and no side effects were noted.

#### Conclusions

The combination of an RGTA (Cacicol20) with a BCL seems to be an effective treatment for PED.

Key Words: regenerative agent (RGTA), Cacicol, bandage contact lens (BCL), persistent epithelial defect (PED)

(Cornea 2014;00:1–5)