OTR3® technology stems from understanding the central role of the extracellular matrix in the body’s continued ability to replace a dying cell by another identical cell within a tissue or organ.

This continuous renewal process is regulated by specific signals (or communication peptides such as growth factors) of the extracellular space around the cells. These signals are stored, protected, and positioned on a family of large polysaccharides called Heparan Sulfates, that act as an element of the scaffolding of the extracellular matrix by bridging matrix proteins (such as collagen, elastine , etc…) through binding at a dedicated site existing on each of these proteins.

In cases of injury, specific enzymes called glycanases destroy Heparan Sulfates, that no longer protect the specific signals. Other enzymes called proteases then destroy specific signals along with other structural proteins of the extracellular matrix.